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Inhibition of the intestinal glucose transporters by flavonoids as a possible intervention in diabetes
Authors: Eck, Peter, Zhouyao, Haonan, Granger, Matthew, Shamloo, Maryam, Malunga, Lovemore
Identifier: CSBE17212
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Published in: CSBE-SCGAB Technical Conferences » AGM Winnipeg 2017 (with CIGR VI Technical Symposium)
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Description: In prior work we had shown that intestinal glucose and fructose membrane transporters can be inhibited by plant derived flavonols, specifically myricetin, fisetin, and quercetin. The inhibition was noncompetitive, and quercetin itself was not transported by the three major intestinal glucose transporters. Expanding on this work, we demonstrate that various extracts from food items can inhibit the glucose uptake into a model of intestinal epithelial cells, CaCo-2E. We conclude that the dominant intestinal sugar transporters can be inhibited by dietary compounds which are inefficiently absorbed and naturally present in foods. The inhibition of the major intestinal glucose transporters by quercetin leads to a blunted postprandial blood glucose rise in a rat model of diabetes type2, indicating that those food compounds improve the glycemic index of foods. These food components show promise as new nutraceutical or pharmacologic agents in obesity. Specific formulations with maximal efficacy to target each intestinal glucose transporter could be developed in the future.
Keywords: flavonoids, glucose, diabetes
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Date: 2017-08-07
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Conference name: CSBE/SCGAB 2017 Annual Conference, Canad Inns Polo Park, Winnipeg, Manitoba, 6-10 August 2017.
Session name: Session 4B: Functional Foods, Nutrition, and Consumers
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Type: Text.Article
Format: PDF
Publication type: Technical conference
Source:
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Coverage: Canada
Language 1: en
Language 2:
Rights: Canadian Society for Bioengineering
Notes:
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DOI:
Description: In prior work we had shown that intestinal glucose and fructose membrane transporters can be inhibited by plant derived flavonols, specifically myricetin, fisetin, and quercetin. The inhibition was noncompetitive, and quercetin itself was not transported by the three major intestinal glucose transporters. Expanding on this work, we demonstrate that various extracts from food items can inhibit the glucose uptake into a model of intestinal epithelial cells, CaCo-2E. We conclude that the dominant intestinal sugar transporters can be inhibited by dietary compounds which are inefficiently absorbed and naturally present in foods. The inhibition of the major intestinal glucose transporters by quercetin leads to a blunted postprandial blood glucose rise in a rat model of diabetes type2, indicating that those food compounds improve the glycemic index of foods. These food components show promise as new nutraceutical or pharmacologic agents in obesity. Specific formulations with maximal efficacy to target each intestinal glucose transporter could be developed in the future.
Keywords: flavonoids, glucose, diabetes
Résumé:
Mots-clés:
Citation:
Volume:
Issue:
Pages -
Contributor:
Date: 2017-08-07
Technical field:
Conference name: CSBE/SCGAB 2017 Annual Conference, Canad Inns Polo Park, Winnipeg, Manitoba, 6-10 August 2017.
Session name: Session 4B: Functional Foods, Nutrition, and Consumers
Other information:
Type: Text.Article
Format: PDF
Publication type: Technical conference
Source:
Relation:
Coverage: Canada
Language 1: en
Language 2:
Rights: Canadian Society for Bioengineering
Notes:
Other files:
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