Electrospun nanofibers of blends of microbial biopolymers for biomedical applications.
Authors: Li, Wei; Cicek, Nazim; Levin, David B; Liu, Song
Description: Polyhydroxyalkanoates (PHAs), a class of microbial biopolymers, have recently attracted significant attention due to their biodegradability, biocompatibility, and renewability. Electrospinning has been used to produce nano-fibrous mats for biomedical applications. Electrospun short chain-length (scl-)PHAs has been extensively investigated. But high crystallinity and brittleness has restricted their applications. Medium chain length (mcl-)PHAs are less crystalline and more flexible, but not suitable for electrospinning since they show tacky and elastomeric at room temperature. Blending (mcl-)PHA with (scl-)PHA is a good way to remain electrospinnable while enhancing their physical and mechanical properties. In this research, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV12, with 12 mol% HV content, (scl-)PHA), PHBV25 (with 25 mol% HV, (scl-)PHA), and blends of PHBV25 with poly(3-hydroxyoctanoate-co-3-hydroxyhexanoate) (PHOHHx, (mcl-)PHA) were electrospun into PHBV12, PHBV25 and PHBV25/PHOHHx nano-fibrous mats. PHBV25/PHOHHx blends were carried out at different ratios, among which PHBV25/PHOHHx (75/25 wt%) is the optimal one. Various electrospinning processing parameters affected morphology of as-spun PHBV25/PHOHHx (75/25 wt%) nano-fibers. As concentration increased from 7.5 to 15% (w/v), bead-free and smooth nano-fibers were obtained. Increase in applied voltage (from 15.5 to 33.5 kV) decreased nanofiber average diameter from 660.6
Keywords: Polyhydroxyalkanoates, Nanofibers, Electrospinning, Biomedical materials
Conference name: CSBE/SCGAB 2017 Annual Conference, Canad Inns Polo Park, Winnipeg, Manitoba, 6-10 August 2017.
Session name: Session 1A: Biopolymers: Production & Properties
Publisher: Canadian Society for Bioengineering
Language 1: en
Rights: Canadian Society for Bioengineering